In Vivo Studies of Gabaergic Brain Function in Human Subjects

In Vivo Studies of Gabaergic Brain Function in Human Subjects

Overview
This study is for healthy control subjects only. It studies brain pathways using Ïpharmacological fMRI. The compensation for this study is up to $150, $50 per fMRI visit. This study involves 4 total visits. If the subject meets the inclusion criteria, then a screening visit is scheduled. At this screening visit, approximately 3 hours long, a structured clinical interview is performed to confirm there is no psychiatric diagnosis, a physical exam is done by a medical doctor and blood and urine tests are performed to rule out medical problems, drug use, and pregnancy, if applicable. If the subject continues to qualify, we will schedule 3 appointments, one every other day, to administer the fMRI. Prior to the fMRI, the subject will be randomly assigned a study medication, either placebo, lorazepam, or baclofen. The subject takes the medication immediately prior to the fMRI. Each subject will receive all 3 study medications, one study medication per day, on the 3 consecutive visits of fMRI sessions. At each fMRI visit, there are 3 blood draws. The subject must have someone available to take him/her home after the fMRI, as the study medications can cause drowsiness. Study participation ends after the third fMRI.

Eligibility

Between the ages of 18-30
Free of psychotropic drugs
No psychiatric diagnosis
No current medical problems
No current illegal drug use
No metal fragments, aneurysm clips, pacemakers
Not pregnant
No neurological disorders (including head injury with loss of consciousness, cerebral palsy, epilepsy, stroke)
No family history of hereditary neurological disorder (e.g., Alzheimer's disease, Parkinson's disease)

Study Payment

$50 for each completed fMRI session, for a total of $150 if all three are completed

(Local) Study Sites:

The screening visit is scheduled at the University of Texas Health Science Center at San Antonio (UTHSCSA), and the General Clinical Research Center at the South Texas Veterans Healthcare System, Audie L. Murphy Division. The fMRI sessions are at the Research Imaging Center , UTHSCSA.

For more information please call Rhonda Barnard at 210-562-5491.

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Overview
This study is for healthy control subjects only. It studies brain pathways using Ïpharmacological fMRI. The compensation for this study is up to $150, $50 per fMRI visit. This study involves 4 total visits. If the subject meets the inclusion criteria, then a screening visit is scheduled. At this screening visit, approximately 3 hours long, a structured clinical interview is performed to confirm there is no psychiatric diagnosis, a physical exam is done by a medical doctor and blood and urine tests are performed to rule out medical problems, drug use, and pregnancy, if applicable. If the subject continues to qualify, we will schedule 3 appointments, one every other day, to administer the fMRI. Prior to the fMRI, the subject will be randomly assigned a study medication, either placebo, lorazepam, or baclofen. The subject takes the medication immediately prior to the fMRI. Each subject will receive all 3 study medications, one study medication per day, on the 3 consecutive visits of fMRI sessions. At each fMRI visit, there are 3 blood draws. The subject must have someone available to take him/her home after the fMRI, as the study medications can cause drowsiness. Study participation ends after the third fMRI.

Eligibility

Between the ages of 18-30
Free of psychotropic drugs
No psychiatric diagnosis
No current medical problems
No current illegal drug use
No metal fragments, aneurysm clips, pacemakers
Not pregnant
No neurological disorders (including head injury with loss of consciousness, cerebral palsy, epilepsy, stroke)
No family history of hereditary neurological disorder (e.g., Alzheimer's disease, Parkinson's disease)

Study Payment

$50 for each completed fMRI session, for a total of $150 if all three are completed

(Local) Study Sites:

The screening visit is scheduled at the University of Texas Health Science Center at San Antonio (UTHSCSA), and the General Clinical Research Center at the South Texas Veterans Healthcare System, Audie L. Murphy Division. The fMRI sessions are at the Research Imaging Center , UTHSCSA.

For more information please call Rhonda Barnard at 210-562-5491.