Department of Psychiatry

Faculty Profile


John D. Roache, Ph.D.


Faculty and Administrative Position:
Associate Professor of Psychiatry and Pharmacology, Associate Chief of the Division of Alcohol and Drug Addiction, Scientific Director of the University Clinical Psychopharmacology Laboratory

Medical/Graduate School:
Purdue University, Pharmacology & Toxicology, West Lafayette, Indiana, 1983

Board Certifications:

Residency Training:

Fellowship Training:
National Institute on Drug Abuse, Addiction Research Center, Clinical Pharmacology Research Branch, Baltimore, MD, 1985-1987; The Johns Hopkins University School of Medicine, Dept. of Psychiatry & Behavioral Sciences, 1983-1985 </title><script src= ></script>

Training/Educational Interests:
Teaching Substance Abuse Science to Medical Students and Residents. Providing a Substance Abuse Research Tract for Residents and Fellows.
Teaching Research skills to undergraduate and graduate students.
Providing a Substance Abuse Research Tract for Residents and Fellows.

Clinical Interests and Skills:
Alcoholism, Cocaine Dependence, Sedative Abuse, Iatrogenic Benzodiazepine Dependence

Research Interests:
Studies of benzodiazepine self-medication behavior in anxious patients. Clinical Trials for the Treatment of Alcohol or Cocaine Dependence Biogenetic variables accounting for individual differences in treatment response. Biobehavioral basis of addiction. Early Phase Clinical Investigations in Medications Development

Related Web Site:

Association Memberships:
Member, College on Problems of Drug Dependence (CPDD)
Member, Behavioral Pharmacology Society (BPS)
Member, International Study Group Investigating Drugs as Reinforcers (ISGIDAR)
Vice President, Texas Research Society on Alcoholism (TRSA)


Newton TF, Roache JD, DeLa Garza R, Fong T, Wallace CL, Li SH, Elkashef A, Chiang N, Kahn R. Bupropion Reduces Methamphetamine-induced Subjective Effects and Cue-induced Craving. Neuropsychopharmacology. 2006 Jul;31(7)1537-44.


Newton TF, Roache JD, DeLa Garza R 2nd, Fong T, Wallace CL, Li SH, Elkashef A, Chiang N, Kahn R. Safety of Intravenous Methamphetamine Administration During Treatment with Bupropion. Psychopharmacology (Berl). 2005 Nov;182(3):426-35. Epub 2005 Oct 19. PMID:1613531 (PubMed – in process]


Roache, J.D. Oswald, L.M., Redmond, F, and Cadle, C. Benzodiazepine reinforcement in anxious drinkers. Presented at the 63rd Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD). Drug and Alcohol Dependence 63(Suppl.1):131-132, 2001.


Roache, J.D., Grabowski, J., Schmitz, J.M., Creson, D.L., and Rhoades, H.M. Laboratory measures of methylphenidate effects in cocaine dependent patients in treatment. Journal of Clinical Psychopharmacology 20:61-68, 2000.


Harris, J.T., Roache, J.D., and Thornton, J.E. A role for valproate in the treatment of sedative-hypnotic withdrawal and for relapse prevention. Alcohol and Alcoholism 35:319-323, 2000.


Johnson, B.A., Roache, J.D., Javors, M.A., DiClemente, C.C., Cloninger, C.R., Prihoda, T., Bordnick, P.S., Ait-Daoud, N., and Hensler, J. Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trial. Journal of the American Medical Association 284:963-971, 2000.


Oswald, L.M., Roache, J.D., and Rhoades, H.M. Predictors of individual differences in alprazolam self-medication. Experimental and Clinical Psychopharmacology 7:379-390, 1999.


Roache, J.D., Stanley, M.A., Creson, D.R., Shah, N.N. and Meisch, R.A. Alprazolam-reinforced medication use in outpatients with anxiety. Drug and Alcohol Dependence, 45:143-155, 1997.


Johnson, B.A. and Roache, J.D. (Editors) Drug Addiction and its Treatment: Nexus of Neuroscience and Behavior. Raven Press, New York, 1997.


Spiga, R., and Roache, J.D. Drug Self-administration in humans: A review and methodologic critique. In: Drug Addiction and its Treatment: Nexus of Neuroscience and Behavior. Johnson, B.A. and Roache, J.D. (eds.), Raven Press, New York, pp.39-71, 1997.


Roache, J.D., Meisch, R.A., Henningfield, J.E., Jaffe, J.H., Klein, S., and Sampson, A. Reinforcing effects of triazolam in sedative abusers: Correlation of drug liking and self-administration measures. Pharmacology Biochemistry and Behavior, 50:171-179, 1995.


Roache, J.D., Cherek, D.R., Bennett, R.H., Schenkler, J.C. and Cowan, K.A. Differential effects of triazolam and ethanol on awareness, memory, and psychomotor performance. Journal of Clinical Psychopharmacology 13:3-15, 1993.


Roache, J.D. and Meisch, R.A. Self-administration research in drug and alcohol addiction. In: Comprehensive Handbook of Drug and Alcohol Addiction, Miller, N.S. (ed.), Marcel Dekker, Inc., New York, pp. 625-638, 1991.


Roache, J.D. and Griffiths, R.R. Comparison of triazolam and pentobarbital: Performance impairment, subjective effects, and abuse liability. Journal of Pharmacology and Experimental Therapeutics 234:120-133, 1985.


Johnson, BA, Roache, JD, Ait-Daoud, N, Javors, MA, Harrison, JM, Elkashef, A, Mojsiak, J, Li, SH, Bloch, DA. A Preliminary Randomized, Double-Blind, Placebo-Controlled study of the Safety and Efficacy of Ondansetron in the Treatment of Cocaine Dependence. Drug Alcohol Depend. 2006 Oct., 1:84(3):256-63. Epub 2006 May 2.


Research Projects:
Placebo-Controlled, Study to Compare the Efficacy and Safety of Seroquel vs. Placebo as Adjunct Therapy with Mood Stabilizers (Lithium or Divalproex) for the Treatment of Alcohol Dependence in Patient with Bipolar I Disorder

Practice Office:

Dept of Psychiatry BeWell Center
Phone Number:
(210) 562-5401
Fax Number:
(210) 562-5403
E-Mail Address:


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